Factor XIII and tissue transglutaminase antibodies in coeliac and inflammatory bowel disease.
Författare
Summary, in English
issue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial antibody (EMA)-negative controls and a group with inflammatory bowel disease (34 with Crohn's disease and 23 with ulcerative colitis). IgA-antibodies against tTg correlated with EMA titres and had high sensitivity and specificity in screening for CD. Only in two CD patients were high titres found of IgA-antibodies against factor XIII, non-reactive with tTg. Both lacked bleeding tendency. The presence of IgG-antibodies against tTg, in contrast, had low sensitivity and specificity in screening for CD and were frequently seen in inflammatory bowel disease. Similarly, factor XIII IgG-antibodies displayed a non-specific pattern with modestly elevated titres in patients with Crohn's disease and in both EMA-negative and positive patients. Despite a marked homology with tTg, the occurrence of high titre IgA-antibodies against factor XIII is infrequent in CD, but may--when present--be the result of epitope spreading. The presence of IgG-antibodies in CD and inflammatory bowel disease illustrates the complexity of autoantibody reactions in gastrointestinal disease.
Avdelning/ar
- Chronic Inflammatory and Degenerative Diseases Research Unit
- Gastroenterologi
- Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG
Publiceringsår
2002
Språk
Engelska
Sidor
357-364
Publikation/Tidskrift/Serie
Autoimmunity
Volym
35
Issue
5
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Taylor & Francis
Ämne
- Rheumatology and Autoimmunity
Nyckelord
- Autoimmunity
- Coeliac Disease
- Endomysial Antibodies
- Factor Xiii
- Transglutaminase Antibodies
Status
Published
Forskningsgrupp
- Chronic Inflammatory and Degenerative Diseases Research Unit
- Gastroenterology
ISBN/ISSN/Övrigt
- ISSN: 0891-6934