Factor XIII and tissue transglutaminase antibodies in coeliac and inflammatory bowel disease.

Summary, in English

issue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial antibody (EMA)-negative controls and a group with inflammatory bowel disease (34 with Crohn's disease and 23 with ulcerative colitis). IgA-antibodies against tTg correlated with EMA titres and had high sensitivity and specificity in screening for CD. Only in two CD patients were high titres found of IgA-antibodies against factor XIII, non-reactive with tTg. Both lacked bleeding tendency. The presence of IgG-antibodies against tTg, in contrast, had low sensitivity and specificity in screening for CD and were frequently seen in inflammatory bowel disease. Similarly, factor XIII IgG-antibodies displayed a non-specific pattern with modestly elevated titres in patients with Crohn's disease and in both EMA-negative and positive patients. Despite a marked homology with tTg, the occurrence of high titre IgA-antibodies against factor XIII is infrequent in CD, but may--when present--be the result of epitope spreading. The presence of IgG-antibodies in CD and inflammatory bowel disease illustrates the complexity of autoantibody reactions in gastrointestinal disease.

• Författare: Klas Sjöberg; Sten Eriksson; Birgitta Tenngart; Bodil Roth; Hakon Leffler; Pål Stenberg
• Avdelning/ar: Chronic Inflammatory and Degenerative Diseases Research Unit; Gastroenterologi; Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG
• Publiceringsår: 2002
• Språk: Engelska
• Sidor: 357-364
• Publikation/Tidskrift/Serie: Autoimmunity
• Volym: 35
• Issue: 5
• Länkar: http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12515290&dopt=AbstractPlus; http://dx.doi.org/10.1080/0891693021000005402
• Dokumenttyp: Artikel i tidskrift
• Förlag: Taylor & Francis
• Ämne: Rheumatology and Autoimmunity
• Nyckelord: Autoimmunity; Coeliac Disease; Endomysial Antibodies; Factor Xiii; Transglutaminase Antibodies
• Status: Published
• Forskningsgrupp: Chronic Inflammatory and Degenerative Diseases Research Unit; Gastroenterology
• ISBN/ISSN/Övrigt: ISSN: 0891-6934