Anatomically-adapted Graph Wavelets for Improved Group-level fMRI Activation Mapping
Författare
Summary, in English
A graph based framework for fMRI brain activation mapping is presented. The approach exploits the spectral graph wavelet transform (SGWT) for the purpose of defining an advanced multi-resolutional spatial transformation for fMRI data. The framework extends wavelet based SPM (WSPM), which is an alternative to the conventional approach of statistical parametric mapping (SPM), and is developed specifically for group-level analysis. We present a novel procedure for constructing brain graphs, with subgraphs that separately encode the structural connectivity of the cerebral and cerebellar grey matter (GM), and address the inter-subject GM variability by the use of template GM representations. Graph wavelets tailored to the convoluted boundaries of GM are then constructed as a means to implement a GM-based spatial transformation on fMRI data. The proposed approach is evaluated using real as well as semi-synthetic multi-subject data. Compared to SPM and WSPM using classical wavelets, the proposed approach shows superior type-I error control. The results on real data suggest a higher detection sensitivity as well as the capability to capture subtle, connected patterns of brain activity.
Avdelning/ar
Publiceringsår
2015
Språk
Engelska
Sidor
185-199
Publikation/Tidskrift/Serie
NeuroImage
Volym
123
Issue
Online 07 June 2015
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Medical Image Processing
Nyckelord
- wavelet thresholding
- graph wavelets
- spectral graph theory
- functional MRI
- statistical parametric mapping (SPM)
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1095-9572