Current progress of adhesins as vaccine candidates for Moraxella catarrhalis

Summary, in English

Moraxello catorrhalis is an emerging pathogen and all isolates are now considered beta-lactamase producing. Potential further use of vaccines against Streptococcus pneumoniae and nontypeable Haemophilus influenzae means that M. catarrhalis might be thrust further into the limelight. However, a vaccine has not yet been designed. In this review, the progress of M. catarrhalis adhesins as vaccine candidates is discussed with a focus on various candidate antigens that spanned those discovered more than 10 years ago, for example, the ubiquitous surface proteins to newer antigens, such as the Moraxella IgD-binding hemagglutinin.

• Författare: Thuan Tong Tan; Kristian Riesbeck
• Avdelning/ar: Klinisk mikrobiologi, Malmö
• Publiceringsår: 2007
• Språk: Engelska
• Sidor: 949-956
• Publikation/Tidskrift/Serie: Expert Review of Vaccines
• Volym: 6
• Issue: 6
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/18377357?dopt=Abstract; http://dx.doi.org/10.1586/14760584.6.6.949
• Dokumenttyp: Artikel i tidskrift
• Förlag: Future Drugs Ltd
• Ämne: Microbiology in the medical area
• Nyckelord: surface protein A1/A2; ubiquitous; outer membrane protein CD; OLpA; IgD binding protein/hag; Moraxella; Moraxella catarrhalis; mcmA; filamentous hemagglutinin; McaP
• Status: Published
• Forskningsgrupp: Clinical Microbiology, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1744-8395