Cystatin C modulates cerebral beta-amyloidosis

Summary, in English

The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions.

• Författare: Stephan A. Kaeser; Martin C. Herzig; Janaky Coomaraswamy; Ellen Kilger; Maj-Linda Selenica; David T. Winkler; Matthias Staufenbiel; Efrat Levy; Anders Grubb; Mathias Jucker
• Avdelning/ar: Avdelningen för klinisk kemi och farmakologi
• Publiceringsår: 2007
• Språk: Engelska
• Sidor: 1437-1439
• Publikation/Tidskrift/Serie: Nature Genetics
• Volym: 39
• Issue: 12
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/18026102; http://www.hih-tuebingen.de/fileadmin/files/Presse/Dokumente/ng.2007.23.pdf; http://www.nature.com/ng/journal/v39/n12/full/ng.2007.23.html; http://dx.doi.org/10.1038/ng.2007.23
• Dokumenttyp: Artikel i tidskrift
• Förlag: Nature Publishing Group
• Ämne: Pharmacology and Toxicology; Medicinal Chemistry
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1546-1718