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Interferon-gamma inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism

In English

Författare

  • Jesper A. B. Strickertsson
  • Kristina B. V. Dossing
  • Anna J. M. Aabakke
  • Hans-Olof Nilsson
  • Thomas V. O. Hansen
  • Ulrich Knigge
  • Andreas Kjaer
  • Torkel Wadström
  • Lennart Friis-Hansen

Summary, in English

AIM: To investigate if and how the proinflammatory cytokine interferon gamma (IFN gamma) affects ghrelin expression in mice. METHODS: The plasma concentration of ghrelin, and gastric ghrelin and somatostatin expression, were examined in wild-type mice and mice infected with Helicobacter pylori (H. pylon). Furthermore, ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth. To study the effect of IFN gamma alone, mice were given a subcutaneous infusion of IFN gamma for 7 d. Finally, the influence of IFN gamma, and somatostatin on the ghrelin promoter was characterized. RESULTS: H. pylori infection was associated with a 50% reduction in ghrelin expression and plasma concentration. Suppression of ghrelin expression was inversely correlated with gastric inflammation in achlorhdyric mouse models. Subcutaneous infusion of IFN gamma suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations. Finally, we showed that the ghrelin promoter operates under the control of somatostatin but not under that of IFN gamma. CONCLUSION: Gastric infection and inflammation is associated with increased IFN gamma expression and reduced ghrelin expression. IFN gamma does not directly control ghrelin expression but inhibits it indirectly via somatostatin. (C) 2011 Baishideng. All rights reserved.

Publiceringsår

2011

Språk

Engelska

Sidor

3117-3125

Publikation/Tidskrift/Serie

World Journal of Gastroenterology

Volym

17

Issue

26

Dokumenttyp

Artikel i tidskrift

Förlag

WJG Press

Ämne

  • Gastroenterology and Hepatology

Nyckelord

  • Ghrelin
  • Interferon-gamma
  • Somatostatin
  • Inflammatory diseases
  • Helicobacter pylori

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1007-9327