Low glutathione peroxidase in rdl mouse retina increases oxidative stress and proteases
Författare
Summary, in English
Malondialdehyde, reduced glutathione, glutathione peroxidase, glutathione reductase and cysteine protease cathepsins at postnatal (PN) days 2, 7, 14, 21 and 28 in controls (wt) and the retinal degeneration 1 (rd1) mouse model for retinitis pigmentosa retinas were measured to determine oxidative stress. In PN28 wt and PN2 rd1 retinas, elevated malondialdehyde and low glutathione peroxidase activity indicate higher oxidative load, despite higher reduced glutathione in PN2 rd1 retinas. This is due to physiological exposure to light and retinal vascular/neural restructuring, respectively. Compared with wt retinas, relatively high malondialdehyde at PN2 and cathepsin levels at PN14, 21 and 28 in rd1 retinas indicate that cells of the residual inner retina also contribute to the oxidative stress and retinal degeneration.
Avdelning/ar
Publiceringsår
2007
Språk
Engelska
Sidor
797-801
Publikation/Tidskrift/Serie
NeuroReport
Volym
18
Issue
8
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Lippincott Williams & Wilkins
Ämne
- Neurosciences
Nyckelord
- retinal degeneration
- stress
- oxidative
- malondialdehyde
- cysteine protease
- glutathione system
- rd1 mice
Status
Published
Forskningsgrupp
- Family Medicine and Community Medicine
ISBN/ISSN/Övrigt
- ISSN: 1473-558X