Hematopoietic stem cell aging: Mechanism and consequence
Författare
Summary, in English
Advancing age is frequented by the onset of a variety of hematological conditions characterized by diminished homeostatic control of blood cell production. The fact that upstream hematopoietic stem and progenitor cells are obligate mediators of homeostatic control of all blood lineages, has implicated the involvement of these cells in the pathophysiology of these conditions. Indeed, evidence from our group and others has suggested that two of the most clinically significant age-associated hematological conditions, namely, the diminution of the adaptive immune system and the elevated incidence of myeloproliferative diseases, have their origin in cell autonomous changes in the functional capacity of hematopoietic stem cells.
Avdelning/ar
Publiceringsår
2007
Språk
Engelska
Sidor
385-390
Publikation/Tidskrift/Serie
Experimental Gerontology
Volym
42
Issue
5
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Gerontology, specializing in Medical and Health Sciences
Nyckelord
- lineage
- myeloid
- lymphoid
- side population
- stem cell
- aging
- potential
- leukemia
Status
Published
Forskningsgrupp
- Immunology
ISBN/ISSN/Övrigt
- ISSN: 1873-6815