Ubiquitous Structural Signaling in Bacterial Phytochromes.
Författare
Summary, in English
The phytochrome family of light-switchable proteins has long been studied by biochemical, spectroscopic and crystallographic means, while a direct probe for global conformational signal propagation has been lacking. Using solution X-ray scattering, we find that the photosensory cores of several bacterial phytochromes undergo similar large-scale structural changes upon red-light excitation. The data establish that phytochromes with ordinary and inverted photocycles share a structural signaling mechanism and that a particular conserved histidine, previously proposed to be involved in signal propagation, in fact tunes photoresponse.
Avdelning/ar
Publiceringsår
2015
Språk
Engelska
Sidor
3379-3383
Publikation/Tidskrift/Serie
The Journal of Physical Chemistry Letters
Volym
6
Issue
17
Dokumenttyp
Artikel i tidskrift
Förlag
The American Chemical Society (ACS)
Ämne
- Biochemistry and Molecular Biology
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1948-7185