Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy
Författare
Summary, in English
Methods. Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. Results. Antibody levels to the IgA-BRs were significantly higher in IgAN patients than controls (P = 0.016), particularly in patients with recent streptococcal infection (P = 0.008). Conclusions. The results suggest that children with IgAN had a previous infection with a streptococcal strain expressing an IgA-binding M protein.
Publiceringsår
2010
Språk
Engelska
Sidor
3434-3436
Publikation/Tidskrift/Serie
Nephrology Dialysis Transplantation
Volym
25
Issue
10
Dokumenttyp
Artikel i tidskrift
Förlag
Oxford University Press
Ämne
- Urology and Nephrology
Nyckelord
- IgA nephropathy
- children
- group A streptococci
- M protein
Status
Published
Forskningsgrupp
- Pediatric Nephrology
ISBN/ISSN/Övrigt
- ISSN: 1460-2385