Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy

Författare

Summary, in English

Methods. Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. Results. Antibody levels to the IgA-BRs were significantly higher in IgAN patients than controls (P = 0.016), particularly in patients with recent streptococcal infection (P = 0.008). Conclusions. The results suggest that children with IgAN had a previous infection with a streptococcal strain expressing an IgA-binding M protein.

Publiceringsår

2010

Språk

Engelska

Sidor

3434-3436

Publikation/Tidskrift/Serie

Nephrology Dialysis Transplantation

Volym

25

Issue

10

Dokumenttyp

Artikel i tidskrift

Förlag

Oxford University Press

Ämne

  • Urology and Nephrology

Nyckelord

  • IgA nephropathy
  • children
  • group A streptococci
  • M protein

Status

Published

Forskningsgrupp

  • Pediatric Nephrology

ISBN/ISSN/Övrigt

  • ISSN: 1460-2385