Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Maternal transfer of antibodies in vertebrates: trans-generational effects on offspring immunity.

In English

Författare

Summary, in English

Maternal effects by which females provide their offspring with non-genetic factors such as hormones, nutrients and antibodies can have an important impact on offspring fitness. In vertebrates, maternal antibodies (matAb) are transferred from the mother, via the placenta, egg yolk or milk during lactation to offspring until they are 2 weeks (birds), 4-10 weeks (rodents) and 9 months (humans) old, respectively. matAb transfer can have direct effects on offspring growth rate in birds and rodents, probably by passively protecting the newborn from common pathogens before their endogenous immune system has matured. Indirect long-term effects of matAb transfer on the offspring's own immunity can be synergistic, if matAb act as antigen templates of the accumulated immunological experience of the mother and educate the newborn's immune system. However, it may also be suppressive if matAb reduce antigen presentation to the newborn resulting in antigen-specific blocking of offspring endogenous immunity. Our aim is to review the mechanisms and direct effects of matAb transfer in vertebrates with an emphasis on birds, outline a framework for research on the long-term effects of matAb on the endogenous immune system of the mature offspring and encourage ecological and evolutionary studies of matAb transfer in non-domesticated animals.

Publiceringsår

2009

Språk

Engelska

Sidor

51-60

Publikation/Tidskrift/Serie

Philosophical Transactions of the Royal Society B: Biological Sciences

Volym

364

Issue

1513

Dokumenttyp

Artikel i tidskrift

Förlag

Royal Society Publishing

Ämne

  • Biological Sciences

Nyckelord

  • maternal effects
  • offspring growth rate
  • epitope blocking
  • trans-generational effects
  • immune system priming
  • maternal antibody transfer

Status

Published

Projekt

  • Immunoecology

Forskningsgrupp

  • Molecular Ecology and Evolution Lab
  • Life History and Functional Ecology

ISBN/ISSN/Övrigt

  • ISSN: 1471-2970