Baker's Yeast for Sweet Dough Enables Large-Scale Synthesis of Enantiomerically Pure Bicyclo[3.3.1]nonane-2,6-dione

Summary, in English

An improved synthetic procedure of racemic bicyclo[3.3.1]nonane-2,6-dione has been developed. Employing Baker's yeast for sweet dough made it possible to kinetically resolve the racemic compound and to isolate enantiomerically pure (+)-bicyclo[3.3.1]nonane-2,6-dione on a large scale. Furthermore, the developed procedure made it possible to produce (-)-bicyclo[3.3.1]nonane-2,6-dione with an enantiomeric excess of 75%.

• Författare: Carl-Johan Wallentin; Edvinas Orentas; Eugenijus Butkus; Kenneth Wärnmark
• Avdelning/ar: Centrum för analys och syntes
• Publiceringsår: 2009
• Språk: Engelska
• Sidor: 864-867
• Publikation/Tidskrift/Serie: Synthesis
• Issue: 5
• Länkar: http://dx.doi.org/10.1055/s-0028-1083364
• Dokumenttyp: Artikel i tidskrift
• Förlag: Oxford Polytechnic, Oxford
• Ämne: Organic Chemistry
• Nyckelord: synthesis; kinetic resolution; bicyclic compounds; ketones; chirality
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 0039-7881