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Global and 3D Spatial Assessment of Neuroinflammation in Rodent Models of Multiple Sclerosis.

In English

Författare

  • Shashank Gupta
  • Regine Utoft
  • Henrik Hasseldam
  • Anja Schmidt-Christensen
  • Tine Hannibal
  • Lisbeth Hansen
  • Nina Fransén Pettersson
  • Noopur Agarwal-Gupta
  • Björn Rozell
  • Åsa Andersson
  • Dan Holmberg
Visa allt

Summary, in English

Multiple Sclerosis (MS) is a progressive autoimmune inflammatory and demyelinating disease of the central nervous system (CNS). T cells play a key role in the progression of neuroinflammation in MS and also in the experimental autoimmune encephalomyelitis (EAE) animal models for the disease. A technology for quantitative and 3 dimensional (3D) spatial assessment of inflammation in this and other CNS inflammatory conditions is much needed. Here we present a procedure for 3D spatial assessment and global quantification of the development of neuroinflammation based on Optical Projection Tomography (OPT). Applying this approach to the analysis of rodent models of MS, we provide global quantitative data of the major inflammatory component as a function of the clinical course. Our data demonstrates a strong correlation between the development and progression of neuroinflammation and clinical disease in several mouse and a rat model of MS refining the information regarding the spatial dynamics of the inflammatory component in EAE. This method provides a powerful tool to investigate the effect of environmental and genetic forces and for assessing the therapeutic effects of drug therapy in animal models of MS and other neuroinflammatory/neurodegenerative disorders.

Avdelning/ar

Publiceringsår

2013

Språk

Engelska

Publikation/Tidskrift/Serie

PLoS ONE

Volym

8

Issue

10

Dokumenttyp

Artikel i tidskrift

Förlag

Public Library of Science (PLoS)

Ämne

  • Basic Medicine

Status

Published

Projekt

  • 3D imaging of inflammation and autoimmunity

Forskningsgrupp

  • Autoimmunity
  • Immunology

ISBN/ISSN/Övrigt

  • ISSN: 1932-6203