Degradation of neutrophil extracellular traps is decreased in patients with antiphospholipid syndrome.

Summary, in English

A decreased ability to degrade neutrophil extracellular traps (NETs) is seen in a subgroup of patients with systemic lupus erythematosus (SLE) and correlates with the presence of autoantibodies. Antiphospholipid syndrome (APS) can develop secondary to SLE or as a primary disease. In the current study we investigated the ability of sera from patients with APS to degrade NETs. The presence of antibodies against NETs and neutrophil remnants were also determined in the same patients.

• Författare: Jonatan Leffler; Ljudmila Stojanovich; Yehuda Shoenfeld; Gordana Bogdanovic; Roger Hesselstrand; Anna Blom
• Avdelning/ar: Proteinkemi, Malmö; Reumatologi och molekylär skelettbiologi; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publiceringsår: 2014
• Språk: Engelska
• Sidor: 66-70
• Publikation/Tidskrift/Serie: Clinical and Experimental Rheumatology
• Volym: 32
• Issue: 1
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/24295292?dopt=Abstract
• Dokumenttyp: Artikel i tidskrift
• Förlag: Pacini
• Ämne: Rheumatology and Autoimmunity
• Status: Published
• Forskningsgrupp: Protein Chemistry, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1593-098X