A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).
Författare
Summary, in English
The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype for P-glycoprotein inhibitors.
Avdelning/ar
Publiceringsår
2003
Språk
Engelska
Sidor
140-142
Publikation/Tidskrift/Serie
Journal of Natural Products
Volym
66
Issue
1
Dokumenttyp
Artikel i tidskrift
Förlag
The American Chemical Society (ACS)
Ämne
- Organic Chemistry
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0163-3864