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Changes in the Levels of Neurospecific Proteins and in Behavioral Phenomena in Rats with Hepatic Encephalopathy

Publiceringsår: 2011
Språk: Engelska
Sidor: 205-208
Publikation/Tidskrift/Serie: Neurophysiology
Volym: 43
Nummer: 3
Dokumenttyp: Artikel i tidskrift
Förlag: Springer


We showed that, under conditions of experimental chronic hepatitis, excessive increases in the levels of a Ca-binding protein, S-100b, and a neuronal cell adhesion molecule, NCAM, occur in all parts of the brain of Wistar rats. This is accompanied by suppression of locomotor and orientational/research activity of the animals and increase in their stress sensitivity. Treatment by a ketoglutarate and cytoflavin in chronic hepatitis provides a clear neuroprotective effect.


  • Zoology
  • hepatic encephalopathy
  • S-100b
  • NCAM
  • behavior


  • ISSN: 0090-2977

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