Changes in the Levels of Neurospecific Proteins and in Behavioral Phenomena in Rats with Hepatic Encephalopathy
Dokumenttyp: Artikel i tidskrift
We showed that, under conditions of experimental chronic hepatitis, excessive increases in the levels of a Ca-binding protein, S-100b, and a neuronal cell adhesion molecule, NCAM, occur in all parts of the brain of Wistar rats. This is accompanied by suppression of locomotor and orientational/research activity of the animals and increase in their stress sensitivity. Treatment by a ketoglutarate and cytoflavin in chronic hepatitis provides a clear neuroprotective effect.
- hepatic encephalopathy
- ISSN: 0090-2977