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Antileishmanial metabolites from Lantana balansae

In English

Författare

  • Eliana M. Maldonado
  • Efrain Salamanca
  • Alberto Giménez
  • Olov Sterner

Summary, in English

Eleven compounds, 12-oxo-phytodienoic acid (1), persicogenin (2), eriodictyol 3ʹ4ʹ,7-trimethyl ether (3), phytol (4), spathulenol (5), 4-hydroxycinnamic acid (6), onopordin (7), 5,8,4ʹ-trihydroxy-7,3ʹ-dimethoxyflavone (8), quercetin (9), jaceosidin (10), and 8-hydroxyluteolin (11), were isolated from an ethanol extract of Lantana balansae Briq., Verbenaceae, that was found to possess antileishmanial activ-ity. The structures of the compounds were determined by NMR spectroscopy and HR mass spectrometry, and 1, 2, 3, 7, 8 and 9 were investigated for antiprotozoal activity toward promastigotes of Leishmania amazonensis and Leishmania braziliensis. Compound 1 was shown to be the most potent, with the IC50 values 2.0µM toward L. amazonensis and 0.68µM toward L. braziliensis, although less potent than the positive control Amphotericin B. All compounds have been reported previously, but this is the first report of the isolation of a cyclopentenone fatty acid (1) and flavanones (2 and 3) from a Lantana species.

Publiceringsår

2016-01-01

Språk

Engelska

Sidor

180-183

Publikation/Tidskrift/Serie

Brazilian Journal of Pharmacognosy

Volym

26

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Sociedade Brasileira de Farmacognosia

Ämne

  • Pharmaceutical Sciences

Nyckelord

  • 12-oxo-phytodienoic acid
  • Flavonoids
  • L. braziliensis
  • Lantana balansae
  • Leishmania amazonensis

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0102-695X