Oxidative activation of the propolis hapten isoprenyl caffeate
Författare
Summary, in English
The reactions of isoprenyl caffeate, the strongest allergen known to be present in propolis, with plausible functional groups of proteins were studied. The thiols glutathione and cysteine, which add to isoprenyl caffeate after having been oxidised to the corresponding quinone, served as model substances. The structure of the thiol adducts was determined by spectroscopic methods, addition being found to occur at C-2. The results support the hypothesis that the catecholic propolis hapten is a pro-hapten that forms a complete antigen after oxidation to caffeate quinone and addition to nucleophilic groups of proteins.
Publiceringsår
1995
Språk
Engelska
Sidor
34-36
Publikation/Tidskrift/Serie
Acta Dermato-Venereologica
Volym
75
Issue
1
Dokumenttyp
Artikel i tidskrift
Förlag
Medical Journals Limited
Ämne
- Dermatology and Venereal Diseases
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1651-2057