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Use of calcium channel blockers as antihypertensives in relation to mortality and cancer incidence: a population-based observational study

Författare

Summary, in English

Abstract



Purpose

Treatment with blood pressure lowering drugs may reduce morbidity and mortality. However, the efficacy and effectiveness may differ between antihypertensive agents. The current investigation aimed to compare mortality and cancer incidence in hypertensive patients treated with calcium channel blockers (CCB) or with other antihypertensive drugs (AHD).



Methods

All patients in two outpatient clinics treated with AHD who underwent an annual check-up during 1989 or 1990 were selected. Fatal events were identified through 1997 and incident cancers through 1998.



Results

Two hundred and fourteen patients on CCB and 1029 on other AHD were identified. Overall mortality and the combined mortality from myocardial infarction and stroke were higher in CCB users; hazard ratios adjusted for sex, age, co-morbidity and other and risk factors were 1.84 (95% CI 1.25-2.72) and 2.37 (95% CI 1.27-4.44), respectively. The risk estimates for cancer mortality and for cancer incidence did not differ significantly.



Conclusions

Results from clinical trials as well as observational studies, including the present one, indicate a higher mortality risk and a higher cardiovascular morbidity risk associated with use of CCB. Accordingly, CCB should not be regarded as first line drugs in hypertension.

Avdelning/ar

Publiceringsår

2002

Språk

Engelska

Sidor

493-497

Publikation/Tidskrift/Serie

Pharmacoepidemiology and Drug Safety

Volym

11

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Public Health, Global Health, Social Medicine and Epidemiology
  • Environmental Health and Occupational Health

Status

Published

Forskningsgrupp

  • Community Medicine
  • Social Epidemiology

ISBN/ISSN/Övrigt

  • ISSN: 1053-8569