Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Prospective Study of Human Papillomavirus Seropositivity and Risk of Nonmelanoma Skin Cancer

In English

Författare

  • Kristin Andersson
  • Kristina M. Michael
  • Tapio Luostarinen
  • Tim Waterboer
  • Randi Gislefoss
  • Timo Hakulinen
  • Ola Forslund
  • Michael Pawlita
  • Joakim Dillner

Summary, in English

Cutaneous human papillomaviruses (HPVs) have been associated with squamous cell carcinoma (SCC) in case-control studies, but there are limited data from prospective studies assessing whether virus exposure predicts risk of future cancer development. Two major biobanks, the Southern Sweden Microbiology Biobank (1971-2003) and the Janus Biobank (1973-2003) in Norway, containing samples from 850,000 donors, were searched for incident skin cancer for up to 30 years using registry linkages. Altogether, 2,623 donors with samples taken before diagnosis of SCC or basal cell carcinoma (BCC) of the skin were identified. Prediagnostic samples and samples from 2,623 matched controls were tested for antibodies against 33 types of HPV. Baseline seropositivity to HPV types in genus beta species 2 was associated with SCC risk (odds ratio = 1.3, 95% confidence interval: 1.1, 1.7); this was also the case for samples taken more than 18 years before diagnosis (odds ratio = 1.8, 95% confidence interval: 1.1, 2.8). Type-specific persistent seropositivity entailed elevated point estimates for SCC risk for 29 HPV types and decreased point estimates for only 3 types. After multiple hypothesis adjustment, HPV 76 was significantly associated with SCC risk and HPV 9 with BCC risk. In summary, seropositivity for certain HPV types was associated with an increased risk for future development of SCC and BCC.

Avdelning/ar

Publiceringsår

2012

Språk

Engelska

Sidor

685-695

Publikation/Tidskrift/Serie

American Journal of Epidemiology

Volym

175

Issue

7

Dokumenttyp

Artikel i tidskrift

Förlag

Oxford University Press

Ämne

  • Public Health, Global Health, Social Medicine and Epidemiology

Nyckelord

  • beta papillomavirus
  • DNA tumor viruses
  • human papillomavirus

Status

Published

Forskningsgrupp

  • Epidemiology
  • Clinical Microbiology, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 0002-9262