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Cross-sectional study on acrylamide hemoglobin adducts in subpopulations from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Författare

  • Hubert W. Vesper
  • Nadia Slimani
  • Goran Hallmans
  • Anne Tjonneland
  • Antonio Agudo
  • Vassiliki Benetou
  • Sheila Bingham
  • Heiner Boeing
  • Marie-Christine Boutron-Ruault
  • H. Bas Bueno-de-Mesquita
  • Dolores Chirlaque
  • Francoise Clavel-Chapelon
  • Francesca Crowe
  • Dagmar Drogan
  • Pietro Ferrari
  • Ingegerd Johansson
  • Rudolf Kaaks
  • Jakob Linseisen
  • Eiliv Lund
  • Jonas Manjer
  • Amalia Mattiello
  • Domenico Palli
  • Petra H. M. Peeters
  • Sabina Rinaldi
  • Guri Skeie
  • Antonia Trichopoulou
  • Paolo Vineis
  • Elisabet Wirfält
  • Kim Overvad
  • Ulf Strömberg

Summary, in English

Acrylamide exposure was investigated in subgroups of the EPIC study population (510 subjects from 9 European countries, randomly selected and stratified by age, gender, and smoking status) using hemoglobin adducts of acrylamide (HbAA) and its primary metabolite glycidamide (HbGA). Blood samples were analyzed for HbAA and HbGA by HPLC/MS/MS. Statistical models for HbAA and HbGA were developed including body mass index (BMI), educational level, and physical activity. A large variability in acrylamide exposure and metabolism between individuals and country groups was observed with HbAA and HbGA values ranging between 15-623 and 8-377 pmol/g of Hb, respectively. Both adducts differed significantly by country, sex, and smoking status. HbGA values were significantly lower in high alcohol consumers than in moderate consumers. With increasing BMI, HbGA in nonsmokers and HbAA in smokers decreased significantly. In the assessment of potential health effects related to acrylamide exposure, country of origin, BMI, alcohol consumption, sex, and smoking status should be considered.

Publiceringsår

2008

Språk

Engelska

Sidor

6046-6053

Publikation/Tidskrift/Serie

Journal of Agricultural and Food Chemistry

Volym

56

Issue

15

Dokumenttyp

Artikel i tidskrift

Förlag

The American Chemical Society (ACS)

Ämne

  • Agricultural Science, Forestry and Fisheries

Nyckelord

  • smoking
  • Cancer
  • European Prospective Investigation into
  • acrylamide
  • glycidamide
  • alcohol consumption
  • gender

Status

Published

Forskningsgrupp

  • Surgery
  • Nutrition Epidemiology

ISBN/ISSN/Övrigt

  • ISSN: 0021-8561