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Personalised nutrition : status and perspectives

Författare

  • Hans-Georg Joost
  • Michael J. Gibney
  • Kevin D. Cashman
  • Ulf Görman
  • John E. Hesketh
  • Michael Mueller
  • Ben van Ommen
  • Christine M. Williams
  • John C. Mathers

Summary, in English

Personalised, genotype-based nutrition is a concept that links genotyping with specific nutritional advice in order to improve the prevention of nutrition-associated, chronic diseases. This review describes the current scientific basis of the concept and discusses its problems. There is convincing evidence that variant genes may indeed determine the biological response to nutrients. The effects of single-gene variants on risk or risk factor levels of a complex disease are, however, usually small and sometimes inconsistent. Thus, information on the effects of combinations of relevant gene variants appears to be required in order to improve the predictive precision of the genetic information. Furthermore, very few associations between genotype and response have been tested for causality in human intervention studies, and little is known about potential adverse effects of a genotype-derived intervention. These issues need to be addressed before genotyping can become an acceptable method to guide nutritional recommendations.

Publiceringsår

2007

Språk

Engelska

Sidor

26-31

Publikation/Tidskrift/Serie

British Journal of Nutrition

Volym

98

Issue

01

Dokumenttyp

Artikel i tidskrift

Förlag

Cambridge University Press

Ämne

  • Nutrition and Dietetics

Nyckelord

  • disease risk
  • genotype
  • nutrigenetics
  • nutritional recommendations
  • nutrigenomics

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1475-2662