Persistent organic pollutants have dose and CAG repeat length dependent effects on androgen receptor activity in vitro.
Författare
Summary, in English
Recently, the effect of exposure to persistent organic pollutants (POPs) on sperm concentration was only seen in men with a short androgen receptor (AR) gene CAG repeat. In order to investigate whether these effects could be observed also in vitro, we tested the impact of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (4,4'-DDE) on 5α-dihydrotestosterone activated ARs containing 16, 22 and 28 CAG repeats, respectively. Single exposure to 4,4'-DDE had the most pronounced effect on the AR activity containing 16 CAG repeats, whereas 28 CAG was the most sensitive variant when a mixture of the two compounds was added. Thus, our in vitro results have confirmed the in vivo data indicating a CAG repeat length dependent effect of endocrine disrupters on the AR activity.
Avdelning/ar
Publiceringsår
2011
Språk
Engelska
Sidor
293-297
Publikation/Tidskrift/Serie
Reproductive Toxicology
Volym
32
Issue
3
Fulltext
- Available as PDF - 223 kB
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Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Obstetrics, Gynecology and Reproductive Medicine
Status
Published
Forskningsgrupp
- Reproductive medicine, Malmö
- Molecular genetic reproductive medicine, Malmö
ISBN/ISSN/Övrigt
- ISSN: 1873-1708