Hemoglobin induces inflammation after preterm intraventricular hemorrhage by methemoglobin formation.

Författare

Magnus Gram
Snjolaug Sveinsdottir
Karsten Ruscher
Stefan Hansson
Magnus Cinthio
Bo Åkerström
David Ley

Summary, in English

Cerebral intraventricular hemorrhage (IVH) is a major cause of severe neurodevelopmental impairment in preterm infants. To date, no therapy is available that prevents infants from developing serious neurological disability following IVH. Thus, to develop treatment strategies for IVH, it is essential to characterize the initial sequence of molecular events that leads to brain damage. In this study, we investigated extracellular hemoglobin (Hb) as a causal initiator of inflammation in preterm IVH.

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