Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line.

Summary, in English

Studies on beta cell metabolism are often conducted in rodent beta cell lines due to the lack of stable human beta cell lines. Recently, a human cell line, EndoC-βH1, was generated. Here we investigate stimulus-secretion coupling in this cell line, and compare it with that in the rat beta cell line, INS-1 832/13, and human islets.

• Författare: Lotta Andersson; Berengere Valtat; Annika Bagge; Vladimir Sharoyko; David Nicholls; Philippe Ravassard; Raphael Scharfmann; Peter Spégel; Hindrik Mulder
• Avdelning/ar: Diabetes - molekylär metabolism; Translationell Muskel Forskning; EXODIAB: Excellence of Diabetes Research in Sweden
• Publiceringsår: 2015
• Språk: Engelska
• Publikation/Tidskrift/Serie: PLoS ONE
• Volym: 10
• Issue: 3
• Fulltext: - 2 MB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/25803449?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0120879
• Dokumenttyp: Artikel i tidskrift
• Förlag: Public Library of Science (PLoS)
• Ämne: Endocrinology and Diabetes
• Status: Published
• Forskningsgrupp: Diabetes - Molecular Metabolism; Genomics, Diabetes and Endocrinology
• ISBN/ISSN/Övrigt: ISSN: 1932-6203