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Effects of FK506 on regeneration and macrophages in injured rat sciatic nerve.

In English

Författare

Summary, in English

Effects of FK506 [5.0 mg/kg body weight (BW), subcutaneous, daily] on nerve regeneration and presence of macrophages in lesioned rat sciatic nerves were studied. Models of autologous nerve graft or a nerve crush lesion were used and regeneration was evaluated by immunocytochemistry (also used to detect ED1/ED2 macrophages) and sensory pinch reflex test, respectively. Treatment with FK506 did not increase regeneration distance or regeneration rate in the autologous nerve grafts. However, regeneration distances after nerve crush were significantly longer following treatment with FK506. The number of macrophages (ED1/ED2) in nerve grafts increased over time, but treatment with FK506 had limited effects only in the presence of ED2 macrophages. Present and previously published studies may imply that there is a time-related and type-of-injury-related profile of FK506's pro-regenerative effect.

Publiceringsår

2003

Språk

Engelska

Sidor

251-259

Publikation/Tidskrift/Serie

Journal of the Peripheral Nervous System

Volym

8

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Wiley-Blackwell

Ämne

  • Neurosciences

Status

Published

Projekt

  • Nerve regeneration - signal transduktion mechanisms, timing and alternatives to nerve grafts

Forskningsgrupp

  • Neural Interfaces
  • Hand Surgery, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 1085-9489