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Primary sequence differences between Chido and Rodgers variants of tryptic C4d of the human complement system

In English

Författare

Summary, in English

Human tryptic C4d of the Chido and Rodgers variant was fragmented by cyanogen bromide and trypsin. The fragments were characterized by amino acid analysis and sequence determination. Polymorphism between the two genetic variants was detected in 5 positions. Four were closely located (residues 141, 142, 145, 146), where Leu, Ser, Ile, His occurred in the Chido variant and Pro, Cys, Leu, Asp in the Rodgers variant, respectively. In position 94 Gly was found in Chido and Asp in Rodgers. Alignment of the fragments was performed and it is concluded that tryptic C4d of both variants contains 346 residues.

Publiceringsår

1984

Språk

Engelska

Sidor

8-254

Publikation/Tidskrift/Serie

FEBS Letters

Volym

170

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Wiley-Blackwell

Ämne

  • Medicinal Chemistry

Nyckelord

  • Polymorphism
  • Peptide Fragments/*genetics
  • Humans
  • Cyanogen Bromide
  • *Complement C4b
  • Complement C4/*genetics
  • Comparative Study
  • Amino Acid Sequence
  • Blood Group Antigens/*genetics
  • Genetic
  • Research Support
  • Non-U.S. Gov't
  • Trypsin
  • *Variation (Genetics)

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1873-3468