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Rho-guanine nucleotide exchange factors during development: Force is nothing without control.

In English

Författare

Summary, in English

The development of multicellular organisms is associated with extensive rearrangements of tissues and cell sheets. The driving force for these rearrangements is generated mostly by the actin cytoskeleton. In order to permit the reproducible development of a specific body plan, dynamic reorganization of the actin cytoskeleton must be precisely coordinated in space and time. GTP-exchange factors that activate small GTPases of the Rho family play an important role in this process. Here we review the role of this class of cytoskeletal regulators during important developmental processes such as epithelial morphogenesis, cytokinesis, cell migration, cell polarity, neuronal growth cone extension and phagocytosis in different model systems.

Publiceringsår

2010

Språk

Engelska

Sidor

28-43

Publikation/Tidskrift/Serie

Small GTPases

Volym

1

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Landes Bioscience

Ämne

  • Developmental Biology

Nyckelord

  • cytokinesis
  • morphogenesis
  • RhoGEF
  • myosin
  • actin
  • cytoskeleton
  • GTPase

Status

Published

Forskningsgrupp

  • Invertebrate Developmental Biology, Udo Haecker's group

ISBN/ISSN/Övrigt

  • ISSN: 2154-1248