Large deletions involving the regulatory upstream regions of A4GALT give rise to principally novel P1PK-null alleles.
Författare
Summary, in English
Cells of the clinically important p histo-blood group phenotype lack P1, P(k) , and P glycosphingolipid antigens. All cases investigated so far are due to alterations in the 4-α-galactosyltransferase-encoding Exon 3 of A4GALT. Repetitive elements in the genome can mediate DNA rearrangements, the most abundant being the Alu family of repeats.
Publiceringsår
2014
Språk
Engelska
Sidor
1831-1835
Publikation/Tidskrift/Serie
Transfusion
Volym
54
Issue
7
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Wiley-Blackwell
Ämne
- Hematology
Status
Published
Forskningsgrupp
- Transfusion Medicine
ISBN/ISSN/Övrigt
- ISSN: 1537-2995