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Blood transfusion at delivery and risk of subsequent malignant lymphoma in the mother

In English

Författare

Summary, in English

BACKGROUND AND OBJECTIVES: Blood transfusion has been shown to be a risk factor for non-Hodgkin's lymphoma (NHL).

MATERIALS AND METHODS: In a cohort of 77,928 women with bleeding complications at delivery in the period of 1973-1986, subsequent NHL cases were identified and the number was compared with the number expected from national incidence rates. In a case-control study the proportion of transfused NHL cases was compared with the proportion of transfused controls.

RESULTS: The observed number of NHL in the cohort was 18 versus 22.0 expected. Information on transfusion was obtained for 15 of the NHL cases and none (0%) was transfused versus 32 out of 136 controls (23%).

CONCLUSIONS: Blood transfusion at delivery is not a risk factor for NHL. The immune tolerance induced by pregnancy may reduce the risk of NHL associated with the transfusion of allogeneic blood cells.

Publiceringsår

1998

Språk

Engelska

Sidor

145-148

Publikation/Tidskrift/Serie

Vox Sanguinis

Volym

75

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Wiley-Blackwell

Ämne

  • Cancer and Oncology

Nyckelord

  • Adult
  • Blood Transfusion
  • Case-Control Studies
  • Cohort Studies
  • Delivery, Obstetric
  • Female
  • Hodgkin Disease
  • Humans
  • Incidence
  • Lymphoma, Non-Hodgkin
  • Postpartum Hemorrhage
  • Pregnancy
  • Risk Factors
  • Sweden

Status

Published

Forskningsgrupp

  • Lund Melanoma Study Group

ISBN/ISSN/Övrigt

  • ISSN: 0042-9007