Monitoring of polychlorinated biphenyls in human blood plasma: methodological developments and influence of age, lactation, and fish consumption
Författare
Summary, in English
Human plasma samples from 50 wives of fishermen have been analyzed with respect to PCBs. The non-ortho-substituted PCB congeners CB-126 and CB-169 were determined by mass spectrometry in negative ion chemical ionization mode, which demonstrated a limit of detection of 30 fg. The recoveries of the internal standards used for determination of ortho-substituted CBs were approximately 95%. Two methods, one gravimetric and the other based on enzymatic determinations of triglycerides, cholesterol and phospholipids, were compared for the determination of total amount of lipids in the plasma samples; the correlation coefficient was 0.82 and the slope 0.98. For practical reasons, enzymatic determinations are recommended for further use. The total, lipid-adjusted concentrations of PCBs in plasma were influenced by age, total lactation time and consumption of fatty fish from the Baltic Sea.
Publiceringsår
1997
Språk
Engelska
Sidor
329-336
Publikation/Tidskrift/Serie
Archives of Environmental Contamination and Toxicology
Volym
32
Issue
3
Dokumenttyp
Artikel i tidskrift
Förlag
Springer
Ämne
- Medicinal Chemistry
- Environmental Health and Occupational Health
- Pharmacology and Toxicology
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0090-4341