Abolished angiogenicity and tumorigenicity of Burkitt lymphoma by interleukin-10
Författare
Summary, in English
Because of its immunosuppressive properties, interleukin-10 (IL-10) is thought to play an important role in a number of human disease states, including inflammation, autoimmunity, and transplant rejection. In this study, we demonstrate that introduction of human or viral IL-10 genes into Burkitt's lymphoma cells markedly reduced their ability to grow as subcutaneous (sc) tumors in SCID mice. In vivo assays for angiogenesis revealed an inhibition of the angiogenic capacity of the IL-10-transfected lines. Recombinant human IL-10 abolished and viral IL-10 reduced vascular endothelial growth factor (VEGF)-165-induced neovascularization. Furthermore, IL-10 blocked the VEGF- and fibroblast growth factor (FGF)-2-induced proliferation of microvascular endothelial cells in vitro. The current observations suggest a direct role for IL-10 in the prevention of angiogenesis in human lymphoid malignancies.
Avdelning/ar
Publiceringsår
2000-10-01
Språk
Engelska
Sidor
73-2568
Publikation/Tidskrift/Serie
Blood
Volym
96
Issue
7
Dokumenttyp
Artikel i tidskrift
Förlag
American Society of Hematology
Ämne
- Cancer and Oncology
Nyckelord
- Animals
- Burkitt Lymphoma
- Cell Division
- Cell Line
- Endothelial Growth Factors
- Endothelium, Vascular
- Fibroblast Growth Factor 2
- Gene Expression
- Interleukin-10
- Killer Cells, Natural
- Lymphokines
- Mice
- Mice, SCID
- Neoplasm Transplantation
- Neovascularization, Pathologic
- Rabbits
- Recombinant Proteins
- Transfection
- Tumor Cells, Cultured
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0006-4971