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Abolished angiogenicity and tumorigenicity of Burkitt lymphoma by interleukin-10

In English

Författare

  • L Cervenak
  • L Morbidelli
  • D Donati
  • S Donnini
  • T Kambayashi
  • J L Wilson
  • H Axelson
  • E Castaños-Velez
  • H G Ljunggren
  • R D Malefyt
  • H J Granger
  • M Ziche
  • M T Bejarano
Visa allt

Summary, in English

Because of its immunosuppressive properties, interleukin-10 (IL-10) is thought to play an important role in a number of human disease states, including inflammation, autoimmunity, and transplant rejection. In this study, we demonstrate that introduction of human or viral IL-10 genes into Burkitt's lymphoma cells markedly reduced their ability to grow as subcutaneous (sc) tumors in SCID mice. In vivo assays for angiogenesis revealed an inhibition of the angiogenic capacity of the IL-10-transfected lines. Recombinant human IL-10 abolished and viral IL-10 reduced vascular endothelial growth factor (VEGF)-165-induced neovascularization. Furthermore, IL-10 blocked the VEGF- and fibroblast growth factor (FGF)-2-induced proliferation of microvascular endothelial cells in vitro. The current observations suggest a direct role for IL-10 in the prevention of angiogenesis in human lymphoid malignancies.

Publiceringsår

2000-10-01

Språk

Engelska

Sidor

73-2568

Publikation/Tidskrift/Serie

Blood

Volym

96

Issue

7

Dokumenttyp

Artikel i tidskrift

Förlag

American Society of Hematology

Ämne

  • Cancer and Oncology

Nyckelord

  • Animals
  • Burkitt Lymphoma
  • Cell Division
  • Cell Line
  • Endothelial Growth Factors
  • Endothelium, Vascular
  • Fibroblast Growth Factor 2
  • Gene Expression
  • Interleukin-10
  • Killer Cells, Natural
  • Lymphokines
  • Mice
  • Mice, SCID
  • Neoplasm Transplantation
  • Neovascularization, Pathologic
  • Rabbits
  • Recombinant Proteins
  • Transfection
  • Tumor Cells, Cultured
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0006-4971