Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Identification of gene regions regulating inflammatory microglial response in the rat CNS after nerve injury

In English

Författare

  • Margarita Diez
  • Nada Abdelmagid
  • Karin Harnesk
  • Mikael Strom
  • Olle Lidman
  • Maria Swanberg
  • Rickard Lindblom
  • Faiez Al-Nimer
  • Maja Jagodic
  • Tomas Olsson
  • Fredrik Piehl
Visa allt

Summary, in English

Local CNS inflammation takes place in many neurological disorders and is important for autoimmune neuroinflammation. Microglial activation is strain-dependent in rats and differential MHC class II expression is influenced by variations in the Mhc2ta gene. Despite sharing Mhc2ta and MHC class II alleles, BN and LEW.1N rats differ in MHC class II expression after ventral root avulsion (VRA). We studied MHC class II expression and glial activation markers in BN rats after VRA. Our results demonstrate that MHC class II expression originates from a subpopulation of IBA1(+), ED1(-), and ED2(-) microglia. We subsequently performed a genome-wide linkage scan in an F2(BNxLEW.1N) population, to investigate gene regions regulating this inflammatory response. Alongside MHC class II, we studied the expression of MHC class 1, costimulatory molecules, complement components, microglial markers and Il1b. MHC class II and other transcripts were commonly regulated by gene regions on chromosomes 1 and 7. Furthermore, a common region on chromosome 10 regulated expression of complement and co-stimulatory molecules, while a region on chromosome II regulated MHC class I. We also detected epistatic interactions in the regulation of the inflammatory process. These results reveal the complex regulation of CNS inflammation by several gene regions, which may have relevance for disease. (C) 2009 Elsevier B.V. All rights reserved.

Publiceringsår

2009

Språk

Engelska

Sidor

82-92

Publikation/Tidskrift/Serie

Journal of Neuroimmunology

Volym

212

Issue

1-2

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Neurology

Nyckelord

  • QTL
  • Complement
  • Neuroinflammation
  • MHC class II
  • Gene mapping

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1872-8421