Solvent-free Heck-Jeffery reactions under ball-milling conditions applied to the synthesis of unnatural amino acids precursors and Indoles
Författare
Summary, in English
The syntheses of various amino- and hydroxy-substituted dehydrophenylalanine derivatives using the Heck-Jeffery protocol under non-solvent conditions in a ball mill are presented. The influences of electron-withdrawing groups and of the location of the heteroatom substituent relative to the halide are discussed. Suitably substituted ortho-amino dehydrophenylalanine derivatives undergo a cyclization-elimination reaction to the corresponding 2-substituted indoles.
Avdelning/ar
Publiceringsår
2006
Språk
Engelska
Sidor
1183-1189
Publikation/Tidskrift/Serie
Synthesis
Issue
7
Dokumenttyp
Artikel i tidskrift
Förlag
Oxford Polytechnic, Oxford
Ämne
- Organic Chemistry
Nyckelord
- palladium
- Heck reaction
- green chemistry
- cyclizations
- indoles
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0039-7881