Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Effect of hypoxia on the tumor phenotype: the neuroblastoma and breast cancer models

In English

Författare

Summary, in English

The tumor oxygenation status associates with aggressive behavior. Oxygen shortage, hypoxia, is a major driving force behind tumor vascularization, and hypoxia enhances mutational rate, metastatic spread, and resistance to radiation and chemotherapy. We recently discovered that hypoxia promotes dedifferentiation of neuroblastoma and breast carcinoma cells and development of stem cell-like features. In both these tumor forms there is a correlation between low differentiation stage and poor outcome, and we conclude that the dedifferentiating effect of lowered oxygen adds to the aggressive phenotype induced by hypoxia. With neuroblastoma and breast carcinoma as human tumor model systems, we have addressed questions related to hypoxia-induced molecular mechanisms governing malignant behavior of tumor cells, with emphasis on differentiation and growth control. By global gene expression analyses we are currently screening for gene products exclusively expressed or modified in hypoxic cells with the aim to use them as targets for treatment.

Publiceringsår

2006

Språk

Engelska

Sidor

179-193

Publikation/Tidskrift/Serie

Advances in experimental medicine and biology

Volym

587

Dokumenttyp

Konferensbidrag

Förlag

Springer

Ämne

  • Cancer and Oncology

Nyckelord

  • Animals
  • Anoxia
  • Breast Neoplasms
  • Cell Differentiation
  • Gene Expression Regulation
  • Neoplastic
  • Humans
  • Neuroblastoma
  • Phenotype

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0065-2598