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FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia

Författare

  • Benjamin H. Lee
  • Zuzana Tothova
  • Ross L. Levine
  • Kristina Anderson
  • Natalija Buza-Vidas
  • Dana E. Cullen
  • Elizabeth P. McDowell
  • Jennifer Adelsperger
  • Stefan Frhling
  • Brian J. P. Huntly
  • Miloslav Beran
  • Sten Eirik W Jacobsen
  • D. Gary Gilliland

Summary, in English

Despite their known transforming properties, the effects of leukemogenic FLT3-ITD mutations on hematopoietic stem and multipotent progenitor cells and on hematopoietic differentiation are not well understood. We report a mouse model harboring an ITD in the murine Flt3 locus that develops myeloproliferative disease resembling CMML and further identified FLT3-ITD mutations in a subset of human CMML. These findings correlated with an increase in number, cell cycling, and survival of multipotent stem and progenitor cells in an ITD dose-dependent manner in animals that exhibited alterations within their myeloid progenitor compartments and a block in normal B cell development. This model provides insights into the consequences of constitutive signaling by an oncogenic tyrosine kinase on hematopoietic progenitor quiescence, function, and cell fate.

Publiceringsår

2007

Språk

Engelska

Sidor

367-380

Publikation/Tidskrift/Serie

Cancer Cell

Volym

12

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Cell Press

Ämne

  • Cancer and Oncology

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1878-3686