Genetic studies of body mass index yield new insights for obesity biology.
Författare
- Adam E Locke
- Bratati Kahali
- Sonja I Berndt
- Anne E Justice
- Tune H Pers
- Felix R Day
- Corey Powell
- Sailaja Vedantam
- Martin L Buchkovich
- Jian Yang
- Damien C Croteau-Chonka
- Tonu Esko
- Tove Fall
- Teresa Ferreira
- Stefan Gustafsson
- Zoltán Kutalik
- Jian'an Luan
- Reedik Mägi
- Joshua C Randall
- Thomas W Winkler
- Andrew R Wood
- Tsegaselassie Workalemahu
- Jessica D Faul
- Jennifer A Smith
- Jing Hua Zhao
- Wei Zhao
- Jin Chen
- Rudolf Fehrmann
- Åsa K Hedman
- Juha Karjalainen
- Ellen M Schmidt
- Devin Absher
- Najaf Amin
- Denise Anderson
- Marian Beekman
- Jennifer L Bolton
- Jennifer L Bragg-Gresham
- Steven Buyske
- Ayse Demirkan
- Guohong Deng
- Georg B Ehret
- Bjarke Feenstra
- Mary F Feitosa
- Krista Fischer
- Anuj Goel
- Jian Gong
- Anne U Jackson
- Stavroula Kanoni
- Marcus E Kleber
- Kati Kristiansson
- Unhee Lim
- Vaneet Lotay
- Massimo Mangino
- Irene Mateo Leach
- Carolina Medina-Gomez
- Sarah E Medland
- Michael A Nalls
- Cameron D Palmer
- Dorota Pasko
- Sonali Pechlivanis
- Marjolein J Peters
- Inga Prokopenko
- Dmitry Shungin
- Alena Stančáková
- Rona J Strawbridge
- Yun Ju Sung
- Toshiko Tanaka
- Alexander Teumer
- Stella Trompet
- Sander W van der Laan
- Jessica van Setten
- Jana V Van Vliet-Ostaptchouk
- Zhaoming Wang
- Loïc Yengo
- Weihua Zhang
- Aaron Isaacs
- Eva Albrecht
- Johan Ärnlöv
- Gillian M Arscott
- Antony P Attwood
- Stefania Bandinelli
- Amy Barrett
- Isabelita N Bas
- Claire Bellis
- Amanda J Bennett
- Christian Berne
- Roza Blagieva
- Matthias Blüher
- Stefan Böhringer
- Lori L Bonnycastle
- Yvonne Böttcher
- Heather A Boyd
- Marcel Bruinenberg
- Ida H Caspersen
- Yii-Der Ida Chen
- Robert Clarke
- E Warwick Daw
- Anton J M de Craen
- Graciela Delgado
- Maria Dimitriou
- Alex S F Doney
- Niina Eklund
- Karol Estrada
- Elodie Eury
- Lasse Folkersen
- Ross M Fraser
- Melissa E Garcia
- Frank Geller
- Vilmantas Giedraitis
- Bruna Gigante
- Alan S Go
- Alain Golay
- Alison H Goodall
- Scott D Gordon
- Mathias Gorski
- Hans-Jörgen Grabe
- Harald Grallert
- Tanja B Grammer
- Jürgen Gräßler
- Henrik Grönberg
- Christopher J Groves
- Gaëlle Gusto
- Jeffrey Haessler
- Per Hall
- Toomas Haller
- Goran Hallmans
- Catharina A Hartman
- Maija Hassinen
- Caroline Hayward
- Nancy L Heard-Costa
- Quinta Helmer
- Christian Hengstenberg
- Oddgeir Holmen
- Jouke-Jan Hottenga
- Alan L James
- Janina M Jeff
- Åsa Johansson
- Jennifer Jolley
- Thorhildur Juliusdottir
- Leena Kinnunen
- Wolfgang Koenig
- Markku Koskenvuo
- Wolfgang Kratzer
- Jaana Laitinen
- Claudia Lamina
- Karin Leander
- Nanette R Lee
- Peter Lichtner
- Lars Lind
- Jaana Lindström
- Ken Sin Lo
- Stéphane Lobbens
- Roberto Lorbeer
- Yingchang Lu
- François Mach
- Patrik K E Magnusson
- Anubha Mahajan
- Wendy L McArdle
- Stela McLachlan
- Cristina Menni
- Sigrun Merger
- Evelin Mihailov
- Lili Milani
- Alireza Moayyeri
- Keri L Monda
- Mario A Morken
- Antonella Mulas
- Gabriele Müller
- Martina Müller-Nurasyid
- Arthur W Musk
- Ramaiah Nagaraja
- Markus M Nöthen
- Ilja M Nolte
- Stefan Pilz
- Nigel W Rayner
- Frida Renström
- Rainer Rettig
- Janina S Ried
- Stephan Ripke
- Neil R Robertson
- Lynda M Rose
- Serena Sanna
- Hubert Scharnagl
- Salome Scholtens
- Fredrick R Schumacher
- William R Scott
- Thomas Seufferlein
- Jianxin Shi
- Albert Vernon Smith
- Joanna Smolonska
- Alice V Stanton
- Valgerdur Steinthorsdottir
- Kathleen Stirrups
- Heather M Stringham
- Johan Sundström
- Morris A Swertz
- Amy J Swift
- Ann-Christine Syvänen
- Sian-Tsung Tan
- Bamidele O Tayo
- Barbara Thorand
- Gudmar Thorleifsson
- Jonathan P Tyrer
- Hae-Won Uh
- Liesbeth Vandenput
- Frank C Verhulst
- Sita H Vermeulen
- Niek Verweij
- Judith M Vonk
- Lindsay L Waite
- Helen R Warren
- Dawn Waterworth
- Michael N Weedon
- Lynne R Wilkens
- Christina Willenborg
- Tom Wilsgaard
- Mary K Wojczynski
- Andrew Wong
- Alan F Wright
- Qunyuan Zhang
- Eoin P Brennan
- Murim Choi
- Zari Dastani
- Alexander W Drong
- Per Eriksson
- Anders Franco-Cereceda
- Jesper R Gådin
- Ali G Gharavi
- Michael E Goddard
- Robert E Handsaker
- Jinyan Huang
- Fredrik Karpe
- Sekar Kathiresan
- Sarah Keildson
- Krzysztof Kiryluk
- Michiaki Kubo
- Jong-Young Lee
- Liming Liang
- Richard P Lifton
- Baoshan Ma
- Steven A McCarroll
- Amy J McKnight
- Josine L Min
- Miriam F Moffatt
- Grant W Montgomery
- Joanne M Murabito
- George Nicholson
- Dale R Nyholt
- Yukinori Okada
- John R B Perry
- Rajkumar Dorajoo
- Eva Reinmaa
- Rany M Salem
- Niina Sandholm
- Robert A Scott
- Lisette Stolk
- Atsushi Takahashi
- Toshihiro Tanaka
- Ferdinand M Van't Hooft
- Anna A E Vinkhuyzen
- Harm-Jan Westra
- Wei Zheng
- Krina T Zondervan
- Andrew C Heath
- Dominique Arveiler
- Stephan J L Bakker
- John Beilby
- Richard N Bergman
- John Blangero
- Pascal Bovet
- Harry Campbell
- Mark J Caulfield
- Giancarlo Cesana
- Aravinda Chakravarti
- Daniel I Chasman
- Peter S Chines
- Francis S Collins
- Dana C Crawford
- L Adrienne Cupples
- Daniele Cusi
- John Danesh
- Ulf de Faire
- Hester M den Ruijter
- Anna F Dominiczak
- Raimund Erbel
- Jeanette Erdmann
- Johan G Eriksson
- Martin Farrall
- Stephan B Felix
- Ele Ferrannini
- Jean Ferrières
- Ian Ford
- Nita G Forouhi
- Terrence Forrester
- Oscar H Franco
- Ron T Gansevoort
- Pablo V Gejman
- Christian Gieger
- Omri Gottesman
- Vilmundur Gudnason
- Ulf Gyllensten
- Alistair S Hall
- Tamara B Harris
- Andrew T Hattersley
- Andrew A Hicks
- Lucia A Hindorff
- Aroon D Hingorani
- Albert Hofman
- Georg Homuth
- G Kees Hovingh
- Steve E Humphries
- Steven C Hunt
- Elina Hyppönen
- Thomas Illig
- Kevin B Jacobs
- Marjo-Riitta Jarvelin
- Karl-Heinz Jöckel
- Berit Johansen
- Pekka Jousilahti
- J Wouter Jukema
- Antti M Jula
- Jaakko Kaprio
- John J P Kastelein
- Sirkka M Keinanen-Kiukaanniemi
- Lambertus A Kiemeney
- Paul Knekt
- Jaspal S Kooner
- Charles Kooperberg
- Peter Kovacs
- Aldi T Kraja
- Meena Kumari
- Johanna Kuusisto
- Timo A Lakka
- Claudia Langenberg
- Loic Le Marchand
- Terho Lehtimäki
- Valeriya Lyssenko
- Satu Männistö
- André Marette
- Tara C Matise
- Colin A McKenzie
- Barbara McKnight
- Frans L Moll
- Andrew D Morris
- Andrew P Morris
- Jeffrey C Murray
- Mari Nelis
- Claes Ohlsson
- Albertine J Oldehinkel
- Ken K Ong
- Pamela A F Madden
- Gerard Pasterkamp
- John F Peden
- Annette Peters
- Dirkje S Postma
- Peter P Pramstaller
- Jackie F Price
- Lu Qi
- Olli T Raitakari
- Tuomo Rankinen
- D C Rao
- Treva K Rice
- Paul M Ridker
- John D Rioux
- Marylyn D Ritchie
- Igor Rudan
- Veikko Salomaa
- Nilesh J Samani
- Jouko Saramies
- Mark A Sarzynski
- Heribert Schunkert
- Peter E H Schwarz
- Peter Sever
- Alan R Shuldiner
- Juha Sinisalo
- Ronald P Stolk
- Konstantin Strauch
- Anke Tönjes
- David-Alexandre Trégouët
- Angelo Tremblay
- Elena Tremoli
- Jarmo Virtamo
- Marie-Claude Vohl
- Uwe Völker
- Gérard Waeber
- Gonneke Willemsen
- Jacqueline C Witteman
- M Carola Zillikens
- Linda S Adair
- Philippe Amouyel
- Folkert W Asselbergs
- Themistocles L Assimes
- Murielle Bochud
- Bernhard O Boehm
- Eric Boerwinkle
- Stefan R Bornstein
- Erwin P Bottinger
- Claude Bouchard
- Stéphane Cauchi
- John C Chambers
- Stephen J Chanock
- Richard S Cooper
- Paul I W de Bakker
- George Dedoussis
- Luigi Ferrucci
- Paul Franks
- Philippe Froguel
- Leif Groop
- Christopher A Haiman
- Anders Hamsten
- Jennie Hui
- David J Hunter
- Kristian Hveem
- Robert C Kaplan
- Mika Kivimaki
- Diana Kuh
- Markku Laakso
- Yongmei Liu
- Nicholas G Martin
- Winfried März
- Mads Melbye
- Andres Metspalu
- Susanne Moebus
- Patricia B Munroe
- Inger Njølstad
- Ben A Oostra
- Colin N A Palmer
- Nancy L Pedersen
- Markus Perola
- Louis Pérusse
- Ulrike Peters
- Chris Power
- Thomas Quertermous
- Rainer Rauramaa
- Fernando Rivadeneira
- Timo E Saaristo
- Danish Saleheen
- Naveed Sattar
- Eric E Schadt
- David Schlessinger
- P Eline Slagboom
- Harold Snieder
- Tim D Spector
- Unnur Thorsteinsdottir
- Michael Stumvoll
- Jaakko Tuomilehto
- André G Uitterlinden
- Matti Uusitupa
- Pim van der Harst
- Mark Walker
- Henri Wallaschofski
- Nicholas J Wareham
- Hugh Watkins
- David R Weir
- H-Erich Wichmann
- James F Wilson
- Pieter Zanen
- Ingrid B Borecki
- Panos Deloukas
- Caroline S Fox
- Iris M Heid
- Jeffrey R O'Connell
- David P Strachan
- Kari Stefansson
- Cornelia M van Duijn
- Gonçalo R Abecasis
- Lude Franke
- Timothy M Frayling
- Mark I McCarthy
- Peter M Visscher
- André Scherag
- Cristen J Willer
- Michael Boehnke
- Karen L Mohlke
- Cecilia M Lindgren
- Jacques S Beckmann
- Inês Barroso
- Kari E North
- Erik Ingelsson
- Joel N Hirschhorn
- Ruth J F Loos
- Elizabeth K Speliotes
Summary, in English
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
Avdelning/ar
Publiceringsår
2015
Språk
Engelska
Sidor
197-401
Publikation/Tidskrift/Serie
Nature
Volym
518
Issue
7538
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Nature Publishing Group
Ämne
- Endocrinology and Diabetes
Nyckelord
- Polymorphism
- Obesity: metabolism
- Obesity: genetics
- Insulin: secretion
- Insulin: metabolism
- Glutamic Acid: metabolism
- Genetic Predisposition to Disease: genetics
- Europe: ethnology
- Energy Metabolism: genetics
- Continental Population Groups: genetics
- Adipogenesis: genetics
- Adiposity: genetics
- Single Nucleotide: genetics
- Quantitative Trait Loci: genetics
- Synapses: metabolism
Status
Published
Forskningsgrupp
- Genomics, Diabetes and Endocrinology
- Genetic and Molecular Epidemiology
ISBN/ISSN/Övrigt
- ISSN: 0028-0836