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The impact of nicotine on osseointegration - An experimental study in the femur and tibia of rabbits

In English

Författare

Summary, in English

Objectives: The aim of the present study was to analyze the effect of an enhanced systematic dose of nicotine on osseointegration of titanium implants. Material and methods: Sixteen female rabbits received either nicotine ( n = 8) or saline ( n 8) administered subcutaneously via mini-osmotic pumps for 2 months. The pump delivered 6 mg/kg/min of nicotine for the animals in the test group. Blood was withdrawn and plasma cotinine levels were measured weekly. Thirty-two titanium implants were inserted into the femur and tibia of all rabbits after 4 weeks and after 6 weeks of nicotine/ placebo exposure. Thus, 2- and 4-week healing groups were created. Biomechanical evaluation by (i) resonance frequency analysis test (RFA) on all implants after insertion and before sacrifice and (ii) removal torque test (RMT) on tibial implants before sacrifice was performed. All implants placed in the femur were processed to undecalcified ground sections. The percentage of bone-to-implant contact (BIC) and of bone area within the threads (BD-i) were measured. Results: No significant difference in RMT and RFA values was found between the test and the control group. Histomorphometric measurements of the BIC and the peri-implant BD-i showed no significant differences between the test and the control group after 2 or after 4 weeks. Conclusion: Nicotine exposure for a short period of time even in a high dose did not have a significant impact on implant osseointegration in rabbits.

Publiceringsår

2005

Språk

Engelska

Sidor

389-395

Publikation/Tidskrift/Serie

Clinical Oral Implants Research

Volym

16

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Wiley-Blackwell

Ämne

  • Environmental Health and Occupational Health

Nyckelord

  • test
  • removal torque
  • nicotine
  • implants
  • bone healing
  • histomorphometry
  • resonance frequency analysis
  • smoking

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1600-0501