Cytogenetic findings in pediatric renal cell carcinoma
Författare
Summary, in English
Adenocarcinomas of the kidney are rare childhood tumors. Only 30 cases with chromosomal abnormalities have been reported, and neither their karyotypic characteristics nor the molecular mechanisms behind their pathogenesis are clear, except for a special group of papillary tumors characterized by X-chromosome abnormalities. We have cytogenetically analyzed short-term cultured cells from two pediatric renal carcinomas, one papillary, and one chromophobe renal cell carcinoma, revealing the following karyotypes: 58-60,XX,-X,-1,+7,-8,-9,-11,-14,-15,+17,-18,-19,-21,-22 and 36,X,-X,-1,-2,-5,-6,-9,-10,-13,-17,-21/37,idem,+r/36,idem,-14,+1-2r, respectively. The findings indicate that subsets of pediatric renal cell carcinoma show karyotypes that are similar to their adult counterparts.
Publiceringsår
2007-02
Språk
Engelska
Sidor
75-80
Publikation/Tidskrift/Serie
Cancer Genetics and Cytogenetics
Volym
173
Issue
1
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Cancer and Oncology
- Pediatrics
- Medical Genetics
Nyckelord
- Adolescent
- Carcinoma, Papillary
- Carcinoma, Renal Cell
- Child
- Chromosome Aberrations
- Chromosome Banding
- Humans
- Karyotyping
- Kidney Neoplasms
- Ring Chromosomes
- Tumor Cells, Cultured
- Case Reports
- Journal Article
- Research Support, Non-U.S. Gov't
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0165-4608