Lupus anticoagulants in two children-bleeding due to nonphospholipid-dependent antiprothrombin antibodies.
Författare
Summary, in English
We describe two children with significant bleeding: one with multiple ecchymoses and the other with scrotal bleeding. In both patients, the activated partial thromboplastin time (APTT) was prolonged, with positivity for lupus anticoagulants (LA). However, the Owren prothrombin time (PT), usually insensitive for LA, was also prolonged. The presence of LA is associated with diverse clinical manifestations, with most patients being asymptomatic while others present venous or arterial thrombosis. Bleeding in conjunction with LA is rare and it is unusual to see prolongation of the Owren PT assay due to LA. An extended laboratory investigation of one of the patient's plasma revealed not only LA but also a specific nonphospholipid-dependent antiprothrombin antibody causing an acquired hypoprothrombinemia. Conclusion: It is likely that the low prothrombin activity and not the LA caused the bleeding. The bleeding signs and symptoms in both patients subsided when the PT was normalized, although the prolonged APTT and the LA remained.
Avdelning/ar
- Paediatric Hematologic Research Group
- Klinisk kemi, Malmö
Publiceringsår
2012
Språk
Engelska
Sidor
1383-1387
Publikation/Tidskrift/Serie
European Journal of Pediatrics
Volym
171
Issue
9
Fulltext
- Available as PDF - 133 kB
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Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Springer
Ämne
- Pediatrics
Status
Published
Forskningsgrupp
- Paediatric Hematologic Research Group
- Clinical Chemistry, Malmö
ISBN/ISSN/Övrigt
- ISSN: 1432-1076