Hypoxia down-regulates expression of secretory leukocyte protease inhibitor in bronchial epithelial cells via TGF-β1.
Författare
Summary, in English
Secretory leukocyte protease inhibitor (SLPI) is a protein with anti-protease and antimicrobial properties that is constitutively secreted from the airway epithelium. The importance of maintaining a balance between proteases and anti-proteases, and robust innate defence mechanisms in the airways, is exemplified by inflammatory lung conditions such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Both conditions present with a high protease burden in the airways which leads to tissue destruction. These patients also have an impaired innate immune system in the lungs with bacterial colonization and frequent airway infections. Moreover, both diseases are associated with airway hypoxia due to inflammation and mucus plugs. The aim of the present study was to investigate the role of hypoxia on SLPI production from the airway epithelium.
Avdelning/ar
- Infektionsmedicin
- Avdelningen för translationell cancerforskning
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- Luftvägsinflammation
- Lungmedicin, allergologi och palliativ medicin
Publiceringsår
2015
Språk
Engelska
Publikation/Tidskrift/Serie
BMC Pulmonary Medicine
Volym
15
Issue
1
Fulltext
- Available as PDF - 502 kB
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Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
BioMed Central (BMC)
Ämne
- Respiratory Medicine and Allergy
Status
Published
Forskningsgrupp
- Airway Inflammation and Immunology
ISBN/ISSN/Övrigt
- ISSN: 1471-2466