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Nicotine does not affect plasma lipoprotein concentrations in healthy men

In English

Författare

Summary, in English

The effects of nicotine administration (2 mg eight-times daily as nicotine chewing gum for two weeks) on plasma lipid and lipoprotein concentrations were studied in young healthy volunteers. Plasma levels of the nicotine metabolite, cotinine, reached levels comparable to those seen in smokers. Plasma concentrations of triglyceride, cholesterol, HDL cholesterol, LDL cholesterol, and apolipoproteins AI and B, were determined repeatedly before, during and after cessation of nicotine intake. All these variables, as well as the activities of lipoprotein lipase and hepatic lipase in post-heparin plasma, remained unchanged throughout the study. The results strongly suggest that the effects of smoking on plasma lipoprotein metabolism are not mediated via nicotine, and indicate that nicotine chewing gum, when used therapeutically in anti-smoking programmes, does not carry the same metabolic side effects as smoking.

Publiceringsår

1989

Språk

Engelska

Sidor

149-153

Publikation/Tidskrift/Serie

Scandinavian Journal of Clinical & Laboratory Investigation

Volym

49

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Informa Healthcare

Ämne

  • Pharmacology and Toxicology
  • Endocrinology and Diabetes
  • Medicinal Chemistry

Nyckelord

  • plasma lipoproteins
  • plasma lipids
  • nicotine intake
  • lipolytic enzymes
  • cotinine concentrations

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1502-7686