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GPR30/GPER1: searching for a role in estrogen physiology.

In English

Författare

Summary, in English

Estrogens are sex hormones that are central to health and disease in both genders. These hormones have long been recognized to act in complex ways, both through relatively slow genomic mechanisms and via fast non-genomic mechanisms. Several recent in vitro studies suggest that GPR30, or G protein-coupled estrogen receptor 1 (GPER1), is a functional membrane estrogen receptor involved in non-genomic estrogen signaling. However, this function is not universally accepted. Studies concerning the role of GPER1 in vivo are now beginning to appear but with divergent results. In this review we discuss current knowledge on the physiological role of GPER1 in the nervous system as well as in reproduction, metabolism, bone, and in the cardiovascular and immune systems.

Avdelning/ar

  • Drug Target Discovery

Publiceringsår

2009

Språk

Engelska

Sidor

409-416

Publikation/Tidskrift/Serie

Trends in Endocrinology and Metabolism

Volym

20

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Endocrinology and Diabetes

Status

Published

Forskningsgrupp

  • Drug Target Discovery

ISBN/ISSN/Övrigt

  • ISSN: 1879-3061