New propranolol analogues: binding and chiral discrimination by cellobiohydrolase Cel7A
Författare
Summary, in English
Novel propranolol analogues have been designed and synthesised and their enantioselective binding to the cellulose degrading enzyme, Cel7A, has been evaluated. Affinity and enantioselectivity have been determined by capillary electrophoresis experiments. Ligands with significantly improved affinity and selectivity have been obtained and an analysis of the results has led to insights concerning the relation between the changes in ligand structure and selectivity as well as affinity to the protein.
Avdelning/ar
Publiceringsår
2006
Språk
Engelska
Sidor
3067-3076
Publikation/Tidskrift/Serie
Organic and Biomolecular Chemistry
Volym
4
Issue
16
Dokumenttyp
Artikel i tidskrift
Förlag
Royal Society of Chemistry
Ämne
- Organic Chemistry
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1477-0539