Inhibition of leukocyte phagocytosis by serotonin and its possible role in tumor cell destruction

Summary, in English

Intraportal tumour cell (TC) injection activates platelets which release serotonin (5-HT). Thrombocytopenia or 5-HT blockade decrease the hepatic lodgement of the injected TCs. A hypothetical explanation of this is 5-HT inhibition of TC killing by phagocytes (e.g. leukocytes and Kupffer cells). In this study, leukocyte phagocytosis was analysed by a chemiluminescence technique at different 5-HT concentrations. Significant inhibition of phagocytosis occurred at 5-HT concentrations of 10(-4) M to 10(-8) M, with maximum inhibition at 10(-4) M. Comparable concentrations of 5-HT may be found locally in the liver during TC infusion, supporting the hypothesis that 5-HT has an inhibitory effect on phagocyte-mediated TC killing.

• Författare: U Nannmark; L Sennerby; Lars Magnus Bjursten; G Skolnik; U Bagge
• Publiceringsår: 1992
• Språk: Engelska
• Sidor: 83-86
• Publikation/Tidskrift/Serie: Cancer Letters
• Volym: 62
• Issue: 1
• Länkar: http://dx.doi.org/10.1016/0304-3835(92)90202-7
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Cancer and Oncology
• Nyckelord: lodgement; phagocytes; tumour cells; liver; serotonin (5-HT)
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1872-7980