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Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity

In English

Författare

Summary, in English

The effects of alkylresorcinols (ARs) isolated from rye bran on adipocyte lipolysis, hormone-sensitive lipase activity and phosphorylation and on phosphorylation of protein kinase A substrates were studied. Preincubation with ARs for 18 h suppressed catecholamine-stimulated lipolysis in 3T3-L1 adipocytes. Furthermore, phosphorylation of hormone-sensitive lipase (HSL), a key lipase responsible for stimulated lipolysis, and phosphorylation of protein kinase A substrates, were diminished after preincubation with ARs, whereas HSL protein expression was unaltered. ARs were also shown to inhibit HSL activity in an in vitro assay.

Publiceringsår

2011

Språk

Engelska

Sidor

290-293

Publikation/Tidskrift/Serie

Molecular Nutrition and Food Research

Volym

55

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Nutrition and Dietetics

Nyckelord

  • Adipose tissue
  • Alkylresorcinols
  • Lipolysis
  • Type 2 diabetes
  • Whole
  • grain

Status

Published

Projekt

  • ANTIDIABETIC FOOD CENTRE

Forskningsgrupp

  • Molecular Endocrinology
  • Insulin Signal Transduction

ISBN/ISSN/Övrigt

  • ISSN: 1613-4133