Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk

In English

Författare

  • Judith S. Brand
  • Yvonne T. van der Schouw
  • N. Charlotte Onland-Moret
  • Stephen J. Sharp
  • Ken K. Ong
  • Kay-Tee Khaw
  • Eva Ardanaz
  • Pilar Amiano
  • Heiner Boeing
  • Maria-Dolores Chirlaque
  • Francoise Clavel-Chapelon
  • Francesca L. Crowe
  • Blandine de Lauzon-Guillain
  • Eric J. Duell
  • Guy Fagherazzi
  • Paul Franks
  • Sara Grioni
  • Leif Groop
  • Rudolf Kaaks
  • Timothy J. Key
  • Peter Nilsson
  • Kim Overvad
  • Domenico Palli
  • Salvatore Panico
  • J. Ramon Quiros
  • Olov Rolandsson
  • Carlotta Sacerdote
  • Maria-Jose Sanchez
  • Nadia Slimani
  • Birgit Teucher
  • Anne Tjonneland
  • Rosario Tumino
  • Daphne L. van der A
  • Edith J. M. Feskens
  • Claudia Langenberg
  • Nita G. Forouhi
  • Elio Riboli
  • Nicholas J. Wareham
Visa allt

Summary, in English

OBJECTIVE-Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk. RESEARCH DESIGN AND METHODS-Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied. RESULTS-Mean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04-1.69), 1.09 (0.90-1.31), 0.97 (0.86-1.10), and 0.85 (0.70-1.03) for women with menopause at ages <40, 40-44, 45-49, and >= 55 years, respectively, relative to those with menopause at age 50-54 years. The HR per SD younger age at menopause was 1.08 (1.02-1.14). Similarly, a shorter reproductive life span was associated with a higher diabetes risk (HR per SD lower reproductive life span 1.06 [ 1.01-1.12]). No effect modification by BMI, waist circumference, or smoking was observed (P interaction all > 0.05). CONCLUSIONS-Early menopause is associated with a greater risk of type 2 diabetes. Diabetes Care 36:1012-1019, 2013

Publiceringsår

2013

Språk

Engelska

Sidor

1012-1019

Publikation/Tidskrift/Serie

Diabetes Care

Volym

36

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

American Diabetes Association

Ämne

  • Endocrinology and Diabetes

Status

Published

Forskningsgrupp

  • Genomics, Diabetes and Endocrinology
  • Internal Medicine - Epidemiology

ISBN/ISSN/Övrigt

  • ISSN: 1935-5548