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Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

Författare

  • Cecilia M. Lindgren
  • Iris M. Heid
  • Joshua C. Randall
  • Claudia Lamina
  • Valgerdur Steinthorsdottir
  • Lu Qi
  • Elizabeth K. Speliotes
  • Gudmar Thorleifsson
  • Cristen J. Willer
  • Blanca M. Herrera
  • Anne U. Jackson
  • Noha Lim
  • Paul Scheet
  • Nicole Soranzo
  • Najaf Amin
  • Yurii S. Aulchenko
  • John C. Chambers
  • Alexander Drong
  • Jian'an Luan
  • Helen N. Lyon
  • Fernando Rivadeneira
  • Serena Sanna
  • Nicholas J. Timpson
  • M. Carola Zillikens
  • Jing Hua Zhao
  • Peter Almgren
  • Stefania Bandinelli
  • Amanda J. Bennett
  • Richard N. Bergman
  • Lori L. Bonnycastle
  • Suzannah J. Bumpstead
  • Stephen J. Chanock
  • Lynn Cherkas
  • Peter Chines
  • Lachlan Coin
  • Cyrus Cooper
  • Gabriel Crawford
  • Angela Doering
  • Anna Dominiczak
  • Alex S. F. Doney
  • Shah Ebrahim
  • Paul Elliott
  • Michael R. Erdos
  • Karol Estrada
  • Luigi Ferrucci
  • Guido Fischer
  • Nita G. Forouhi
  • Christian Gieger
  • Harald Grallert
  • Christopher J. Groves
  • Scott Grundy
  • Candace Guiducci
  • David Hadley
  • Anders Hamsten
  • Aki S. Havulinna
  • Albert Hofman
  • Rolf Holle
  • John W. Holloway
  • Thomas Illig
  • Bo Isomaa
  • Leonie C. Jacobs
  • Karen Jameson
  • Pekka Jousilahti
  • Fredrik Karpe
  • Johanna Kuusisto
  • Jaana Laitinen
  • G. Mark Lathrop
  • Debbie A. Lawlor
  • Massimo Mangino
  • Wendy L. McArdle
  • Thomas Meitinger
  • Mario A. Morken
  • Andrew P. Morris
  • Patricia Munroe
  • Narisu Narisu
  • Anna Nordstrom
  • Peter Nordstrom
  • Ben A. Oostra
  • Colin N. A. Palmer
  • Felicity Payne
  • John F. Peden
  • Inga Prokopenko
  • Frida Renstrom
  • Aimo Ruokonen
  • Veikko Salomaa
  • Manjinder S. Sandhu
  • Laura J. Scott
  • Angelo Scuteri
  • Kaisa Silander
  • Kijoung Song
  • Xin Yuan
  • Heather M. Stringham
  • Amy J. Swift
  • Tiinamaija Tuomi
  • Manuela Uda
  • Peter Vollenweider
  • Gerard Waeber
  • Chris Wallace
  • G. Bragi Walters
  • Michael N. Weedon
  • Jacqueline C. M. Witteman
  • Cuilin Zhang
  • Weihua Zhang
  • Mark J. Caulfield
  • Francis S. Collins
  • George Davey Smith
  • Ian N. M. Day
  • Paul Franks
  • Andrew T. Hattersley
  • Frank B. Hu
  • Marjo-Riitta Jarvelin
  • Augustine Kong
  • Jaspal S. Kooner
  • Markku Laakso
  • Edward Lakatta
  • Vincent Mooser
  • Andrew D. Morris
  • Leena Peltonen
  • Nilesh J. Samani
  • Timothy D. Spector
  • David P. Strachan
  • Toshiko Tanaka
  • Jaakko Tuomilehto
  • Andre G. Uitterlinden
  • Cornelia M. van Duijn
  • Nicholas J. Wareham
  • Dawn M. Waterworth
  • Michael Boehnke
  • Panos Deloukas
  • Leif Groop
  • David J. Hunter
  • Unnur Thorsteinsdottir
  • David Schlessinger
  • H. -Erich Wichmann
  • Timothy M. Frayling
  • Goncalo R. Abecasis
  • Joel N. Hirschhorn
  • Ruth J. F. Loos
  • Kari Stefansson
  • Karen L. Mohlke
  • Ines Barroso
  • Mark I. McCarthy

Summary, in English

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P=8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.66x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.

Publiceringsår

2010

Språk

Engelska

Publikation/Tidskrift/Serie

PLoS Genetics

Volym

5

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

Public Library of Science (PLoS)

Ämne

  • Endocrinology and Diabetes

Status

Published

Forskningsgrupp

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Övrigt

  • ISSN: 1553-7404