Författare
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Cecilia M. Lindgren
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Iris M. Heid
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Joshua C. Randall
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Claudia Lamina
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Valgerdur Steinthorsdottir
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Lu Qi
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Elizabeth K. Speliotes
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Gudmar Thorleifsson
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Cristen J. Willer
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Blanca M. Herrera
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Anne U. Jackson
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Noha Lim
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Paul Scheet
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Nicole Soranzo
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Najaf Amin
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Yurii S. Aulchenko
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John C. Chambers
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Alexander Drong
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Jian'an Luan
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Helen N. Lyon
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Fernando Rivadeneira
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Serena Sanna
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Nicholas J. Timpson
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M. Carola Zillikens
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Jing Hua Zhao
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Peter Almgren
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Stefania Bandinelli
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Amanda J. Bennett
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Richard N. Bergman
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Lori L. Bonnycastle
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Suzannah J. Bumpstead
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Stephen J. Chanock
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Lynn Cherkas
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Peter Chines
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Lachlan Coin
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Cyrus Cooper
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Gabriel Crawford
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Angela Doering
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Anna Dominiczak
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Alex S. F. Doney
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Shah Ebrahim
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Paul Elliott
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Michael R. Erdos
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Karol Estrada
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Luigi Ferrucci
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Guido Fischer
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Nita G. Forouhi
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Christian Gieger
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Harald Grallert
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Christopher J. Groves
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Scott Grundy
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Candace Guiducci
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David Hadley
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Anders Hamsten
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Aki S. Havulinna
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Albert Hofman
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Rolf Holle
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John W. Holloway
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Thomas Illig
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Bo Isomaa
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Leonie C. Jacobs
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Karen Jameson
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Pekka Jousilahti
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Fredrik Karpe
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Johanna Kuusisto
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Jaana Laitinen
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G. Mark Lathrop
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Debbie A. Lawlor
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Massimo Mangino
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Wendy L. McArdle
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Thomas Meitinger
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Mario A. Morken
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Andrew P. Morris
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Patricia Munroe
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Narisu Narisu
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Anna Nordstrom
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Peter Nordstrom
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Ben A. Oostra
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Colin N. A. Palmer
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Felicity Payne
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John F. Peden
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Inga Prokopenko
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Frida Renstrom
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Aimo Ruokonen
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Veikko Salomaa
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Manjinder S. Sandhu
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Laura J. Scott
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Angelo Scuteri
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Kaisa Silander
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Kijoung Song
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Xin Yuan
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Heather M. Stringham
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Amy J. Swift
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Tiinamaija Tuomi
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Manuela Uda
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Peter Vollenweider
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Gerard Waeber
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Chris Wallace
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G. Bragi Walters
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Michael N. Weedon
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Jacqueline C. M. Witteman
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Cuilin Zhang
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Weihua Zhang
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Mark J. Caulfield
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Francis S. Collins
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George Davey Smith
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Ian N. M. Day
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Paul Franks
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Andrew T. Hattersley
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Frank B. Hu
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Marjo-Riitta Jarvelin
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Augustine Kong
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Jaspal S. Kooner
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Markku Laakso
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Edward Lakatta
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Vincent Mooser
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Andrew D. Morris
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Leena Peltonen
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Nilesh J. Samani
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Timothy D. Spector
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David P. Strachan
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Toshiko Tanaka
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Jaakko Tuomilehto
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Andre G. Uitterlinden
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Cornelia M. van Duijn
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Nicholas J. Wareham
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Dawn M. Waterworth
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Michael Boehnke
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Panos Deloukas
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Leif Groop
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David J. Hunter
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Unnur Thorsteinsdottir
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David Schlessinger
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H. -Erich Wichmann
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Timothy M. Frayling
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Goncalo R. Abecasis
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Joel N. Hirschhorn
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Ruth J. F. Loos
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Kari Stefansson
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Karen L. Mohlke
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Ines Barroso
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Mark I. McCarthy
Summary, in English
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P=8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.66x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.