Expression of functional toll like receptor 4 in estrogen receptor/progesterone receptor-negative breast cancer.

Summary, in English

Toll-like receptors (TLRs) are a family of pattern recognition receptors that are expressed on cells of the innate immune system. The ligands can be pathogen derived (pathogen associated molecular patterns; PAMPs) or endogenous (damage associated molecular patters; DAMPs) that when bound induces activation of nuclear factor kappa B (NF-κB) and transcription of pro-inflammatory genes. TLRs have also been discovered in various malignant cell types, but with unknown function.

• Författare: Meliha Mehmeti; Roni Allaoui; Caroline Bergenfelz; Lao Saal; Stephen P Ethier; Martin Johansson; Karin Jirström; Karin Leandersson
• Avdelning/ar: Cancerimmunologi, Malmö; Experimentell infektionsmedicin, Malmö; Bröstcancer-genetik; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation; Klinisk patologi, Malmö; Tumörmikromiljö
• Publiceringsår: 2015
• Språk: Engelska
• Publikation/Tidskrift/Serie: Breast Cancer Research
• Volym: 17
• Issue: 1
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/26392082?dopt=Abstract; http://dx.doi.org/10.1186/s13058-015-0640-x
• Dokumenttyp: Artikel i tidskrift
• Förlag: BioMed Central (BMC)
• Ämne: Cancer and Oncology
• Status: Published
• Forskningsgrupp: Cancer Immunology, Malmö; Experimental Infection Medicine, Malmö; Clinical pathology, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1465-5411