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Role of macrophage migration inhibitory factor (MIF) in allergic and endotoxin-induced airway inflammation in mice

In English

Författare

Summary, in English

Macrophage migration inhibitory factor (MIF) has recently been forwarded as a critical regulator of inflammatory conditions, and it has been hypothesized that MIF may have a role in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD). Hence, we examined effects of MIF immunoneutralization on the development of allergen-induced eosinophilic inflammation as well as on lipopolysaccharide (LPS)-induced neutrophilic inflammation in lungs of mice. Anti-MIF serum validated with respect to MIF neutralizing capacity or normal rabbit serum (NRS) was administered i.p. repeatedly during allergen aerosol exposure of ovalbumin (OVA)-immunized mice in an established model of allergic asthma, or once before instillation of a minimal dose of LPS into the airways of mice, a tentative model of COPD. Anti-MIF treatment did not affect the induced lung tissue eosinophilia or the cellular composition of bronchoalveolar lavage fluid (BALF) in the asthma model. Likewise, anti-MIF treatment did not affect the LPS-induced neutrophilia in lung tissue, BALF, or blood, nor did it reduce BALF levels of tumor necrosis factor-alpha (TNF-alpha) and macrophage inflammatory protein-1alpha (MIP-1alpha). The present data suggest that MIF is not critically important for allergen-induced eosinophilic, and LPS-induced neutrophilic responses in lungs of mice. These findings do not support a role of MIF inhibition in the treatment of inflammatory respiratory diseases.

Publiceringsår

2000

Språk

Engelska

Sidor

15-23

Publikation/Tidskrift/Serie

Mediators of Inflammation

Volym

9

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Hindawi Limited

Ämne

  • Pharmacology and Toxicology
  • Medicinal Chemistry

Status

Published

Forskningsgrupp

  • Respiratory Immunopharmacology
  • Neuroendocrine Cell Biology

ISBN/ISSN/Övrigt

  • ISSN: 0962-9351