Studies on the Interactions Between Mucin and Surfactant Aggregates Containing the Cationic Surfactant Dodecyl Betainate
Författare
Summary, in English
The interactions of surfactant aggregates containing the cationic, cleavable surfactant dodecyl betainate (DB) with mucin are investigated. The aggregates were either mixed micelles of DB and the nonionic surfactant PS-80 in different ratios or a dispersion of the commercial self-emulsifying drug-delivery formulation Sandimmun Neoral charged with DB. It is found that for the surfactant aggregates to show any notable interactions with mucin these must have a high positive charge density. Also presented are results from Ussing chamber experiments, which suggest that DB has a limited impact on the integrity and the barrier function of the intestinal epithelium.
Avdelning/ar
Publiceringsår
2009
Språk
Engelska
Sidor
920-928
Publikation/Tidskrift/Serie
Journal of Dispersion Science and Technology
Volym
30
Issue
6
Dokumenttyp
Artikel i tidskrift
Förlag
Taylor & Francis
Ämne
- Physical Chemistry
Nyckelord
- self-emulsifying drug-delivery system
- mucin
- microemulsion
- Bioavailability
- cationic amphiphile
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0193-2691